Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery
نویسندگان
چکیده
منابع مشابه
Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery
BACKGROUND Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol) (MPEG)-doxorubicin (DOX) conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting. METHODS Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic acid end groups of a dendrimer, which was then conjugated with MPEG amine and doxorubicin by aid ...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2015
ISSN: 1178-2013
DOI: 10.2147/ijn.s87145